The clinical manifestations of bone cancer include pain, swelling and deformity, fractures, systemic symptoms, and fatigue. Pain is the most common symptom, even in early stages, and can become more severe and continuous as the disease progresses. The occurrence of swelling and deformity in the bones and joints is also common. Bone fractures can occur even with minor trauma, accompanied by severe pain and swelling, indicating a possible connection to bone cancer.